有柄石韦药膏制备及对大鼠伤口愈合作用的研究
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1.电子科技大学附属医院·四川省人民医院;2.四川大学生命科学学院 资源微生物学与生物技术重点实验室;3.四川省原子能研究院 辐照保藏四川省重点实验室

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R96

基金项目:

四川省原子能研究院辐照保藏四川省重点实验室开放基金(FZBC2020001); 四川省科技厅重点研发项目(2017FZ0059)


Preparation of P.petiolosa ointment and its effect on wound healing in rats
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1.Sichuan Provincial People’s Hospital Affiliated to University of Electronic Science and Technology of China;2.Key Laboratory of Microbiological Resource and Technology, College of Life Sciences, Sichuan University;3.Irradiation Preservation Technology Key Laboratory of Sichuan Province, Sichuan Institute of Atomic Energy

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    摘要:

    利用有柄石韦(Pyrrosia petiolosa, P.petiolosa) 试制药膏,在动物水平研究其抗菌及促伤口愈合的作用.将有柄石韦制备成药膏,构建大鼠皮肤切除创伤模型并随机分为单纯创伤组和金黄色葡萄球菌(Staphylococcus aureus,S.aureus)感染组.各组分别经自然恢复、P.petiolosa药膏、京万红软膏处理后检测大鼠体重与进食情况、创面愈合情况、创面组织病理情况及血清炎性因子的表达情况.结果显示,不同处理组大鼠体重与进食量无显著变化;创面愈合及组织病理学分析显示P.petiolosa药膏可促进单纯创伤组及S.aureus感染组伤口愈合;ELISA结果显示P.petiolosa药膏在致创前期可明显降低炎性反应.结果表明,这款自主研发的以P.petiolosa为主要原料的中药药膏具有很好的拮抗S.aureus和促进伤口愈合的效果.

    Abstract:

    Pyrrosiapetiolosa was used to make ointment to study its antibacterial and wound healing effects at the animal level. The P.petiolosa was prepared into an ointment, and the rat skin excision trauma model was constructed and randomly divided into normal trauma group and Staphylococcus aureus(S.aureus) infection group. Each group was treated with natural recovery, P. petiolosa ointment and Jingwanhong ointment, and then the weight and eating status of rats, wound healing, wound tissue pathology and serum inflammatory factor expression were measured. The results showed that the body weight and food intake of rats in different treatment groups did not change significantly. Wound healing and histopathological analysis showed that P.petiolosa ointment could promote wound healing in normal wound group and S.aureus infection group. ELISA results showed that P.petiolosa ointment group can significantly reduce the inflammatory response in the early stage of trauma. The results demonstrated that this selfdeveloped Chinese medicinal ointment with P.petiolosa as the main raw material has a good effect of antagonizing S.aureus and promoting wound healing.

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引用本文格式: 陈凯,严馨,李天依,冯佰欢,张安东,李姝,王元宵,黄敏,曹玫. 有柄石韦药膏制备及对大鼠伤口愈合作用的研究[J]. 四川大学学报: 自然科学版, 2022, 59: 026005.

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  • 收稿日期:2021-05-10
  • 最后修改日期:2021-07-08
  • 录用日期:2021-07-18
  • 在线发布日期: 2022-04-01
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